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MUTANT SELECTIVITY AND COMBINATIONS OF A PHOSPHOINOSITIDE-3-KINASE INHIBITOR COMPOUND AND CHEMOTHERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER
MUTANT SELECTIVITY AND COMBINATIONS OF A PHOSPHOINOSITIDE-3-KINASE INHIBITOR COMPOUND AND CHEMOTHERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER
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机译：磷酸肌醇-3-激酶抑制剂化合物和化学治疗剂的突变选择性和组合，用于治疗癌症
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摘要
FIELD: medicine.;SUBSTANCE: group of inventions relates to medicine and can be used to treat cancer. Methods, pharmaceutical compositions, uses, an article, a product and a therapeutic combination of the invention relate to the treatment of cancer by the administration of a phosphoinositide-3-kinase (PI3K) inhibitor, GDC-0032 and a chemotherapeutic agent selected from fulvestrant and letrozole.;EFFECT: use of inventions provides the enhanced antitumor activity due to the synergistic effect of the combination.;39 cl, 5 tbl, 44 dwg, 4 ex
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机译：领域：发明领域：一类发明涉及医学并且可以用于治疗癌症。本发明的方法，药物组合物，用途，制品，产品和治疗组合涉及通过施用磷酸肌醇-3-激酶（PI3K）抑制剂，GDC-0032和选自氟司韦特的化学治疗剂来治疗癌症。效果：由于组合的协同作用，发明的使用提供了增强的抗肿瘤活性。; 39 cl，5 tbl，44 dwg，4 ex
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