USE OF MICROORGANISMS TO DECREASE THE TRIMETHYLAMINE RATE IN A HUMAN BODY CAVITY, IN PARTICULAR FOR THE TREATMENT OF TRIMETHYLAMINURIA OR BACTERIAL VAGINOSIS AND THE PREVENTION OF CARDIOVASCULAR DISEASES

摘要

Composition containing a microorganism, preferably a archaea, expressing a tma methyltransferase and a protein corrinoid acceptor of methyl group of tma, capable of metabolizing trimethylamine (tma) in the presence of hydrogen in a human cavity, such as the intestine or the vagina, for use as a medicine to treat reduce or eliminate the tma at the level of the cavity human. This composition is useful for treating the trimethylaminuria, to treat the fluids reported in the case of a bacterial vaginosis and to reduce or eliminate the odours due to the tma. This composition is also useful to reduce the rate of tmao, in order to prevent the formation of the atheroma and / or for the prevention of cardiovascular diseases.