首页> 外国专利> USE OF ANTI-CGRP ANTIBODIES AND ANTIBODY FRAGMENTS TO PREVENT OR INHIBIT PHOTOPHOBIA OR LIGHT AVERSION IN SUBJECTS IN NEED THEREOF, ESPECIALLY MIGRAINE SUFFERERS

USE OF ANTI-CGRP ANTIBODIES AND ANTIBODY FRAGMENTS TO PREVENT OR INHIBIT PHOTOPHOBIA OR LIGHT AVERSION IN SUBJECTS IN NEED THEREOF, ESPECIALLY MIGRAINE SUFFERERS

机译:使用抗CGRP抗体和抗体片段预防或抑制受试者尤其是偏头痛患者的恐惧感或轻度厌恶

摘要

The present invention is directed to methods of inhibiting or preventing photophobia in subjects in need thereof using anti-CGRP antibodies or antibody fragments that inhibit photophobia, especially CGRP-associated photophobia. These antibodies and fragments are useful in treating different disorders associated with photophobia such as migraine, cluster headaches and the like.The present invention also provides assays using transgenic Nestin/Rampl rodents, utilizing a CGRP model light aversive behavior model for identifying therapeutically effective anti-CGRP antibodies and fragments thereof having binding specificity for CGRP which inhibit or prevent photophobia in subjects in need thereof. The present invention is specifically directed to methods for identifying therapeutically effective antibodies and fragments thereof having binding specificity for CGRP that may be used to treat CGRP associated disorders such as migraine. Specifically, this invention relates to assays and therapies using the antibodies described herein to inhibit or prevent photophobia, and binding fragments thereof, comprising the sequences of the V, Vand CDR polypeptides described herein, and the polynucleotides encoding them.
机译:本发明涉及使用抗CGRP抗体或抑制畏光,特别是与CGRP相关的畏光的抗体片段,在有需要的受试者中抑制或预防畏光的方法。这些抗体和片段可用于治疗与恐惧症有关的不同疾病,例如偏头痛,丛集性头痛等。本发明还提供了使用转基因Nestin / Rampl啮齿动物的试验,利用CGRP模型的光厌恶行为模型来鉴定治疗有效的抗具有针对CGRP的结合特异性的CGRP抗体及其片段,其在需要其的受试者中抑制或防止畏光。本发明特别涉及鉴定对CGRP具有结合特异性的治疗有效抗体及其片段的方法,所述抗体及其片段可用于治疗与CGRP相关的疾病例如偏头痛。具体而言,本发明涉及使用本文所述的抗体抑制或预防畏光及其结合片段的测定和疗法,其包含本文所述的V,V和CDR多肽的序列,以及编码它们的多核苷酸。

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