首页> 外国专利> NANO- AND MICRO-SIZED PARTICLES OF 20-CAMPTOTHECIN OR DERIVATIVE THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND TREATMENT OF CANCERS THEREWITH

NANO- AND MICRO-SIZED PARTICLES OF 20-CAMPTOTHECIN OR DERIVATIVE THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND TREATMENT OF CANCERS THEREWITH

机译:20-喜树碱的纳米和微粉化颗粒或包含它们的衍生物和药物成分,并由此治疗癌症

摘要

A pharmaceutical composition is provided having particles of a physical mixture that contain at least one 20-camptothecin or a derivative thereof, at least one surfactant, at least one stabilizer, and at least one diluent. The particles have a mean particle size of less than about 2500 nm. The pharmaceutical composition can be nano- or micro-sized particles containing the 20-camptothecin esters or derivatives thereof as part of a physical mixture, which can provide the active compound in a water-soluble/dispersible, bioavailable form. The particles can be used as an oral pharmaceutical composition which comprises the nano- or micro-sized form of 20-camptothecin esters or derivatives, such as in an oral suspension (e.g., an aqueous suspension), or capsules, or caplets. The pharmaceutical composition can be used in the treatment of a cancer or malignant tumor in a patient by oral administration thereof in a therapeutically effective amount.
机译:提供了一种药物组合物,其具有包含至少一种20-喜树碱或其衍生物,至少一种表面活性剂,至少一种稳定剂和至少一种稀释剂的物理混合物的颗粒。颗粒的平均粒径小于约2500nm。药物组合物可以是包含20-喜树碱酯或其衍生物作为物理混合物的一部分的纳米级或微米级颗粒,其可以以水溶性/可分散的,生物可利用的形式提供活性化合物。所述颗粒可用作口服药物组合物,其包含20-喜树碱酯或衍生物的纳米或微米尺寸形式,例如在口服混悬液(例如水性混悬液)中或在胶囊或囊片中。所述药物组合物可以通过以治疗有效量口服施用来用于治疗患者的癌症或恶性肿瘤。

著录项

  • 公开/公告号EP3350186A4

    专利类型

  • 公开/公告日2019-07-03

    原文格式PDF

  • 申请/专利权人 CAO PHARMACEUTICALS INC.;

    申请/专利号EP20160864794

  • 发明设计人 CHEN WENHAO;ZHANG JIYAO;CAO ZHISONG;

    申请日2016-11-03

  • 分类号A61K31/4745;A61K9/16;

  • 国家 EP

  • 入库时间 2022-08-21 12:30:42

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