首页>
外国专利>
NANO- AND MICRO-SIZED PARTICLES OF 20-CAMPTOTHECIN OR DERIVATIVE THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND TREATMENT OF CANCERS THEREWITH
NANO- AND MICRO-SIZED PARTICLES OF 20-CAMPTOTHECIN OR DERIVATIVE THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND TREATMENT OF CANCERS THEREWITH
展开▼
机译:20-喜树碱的纳米和微粉化颗粒或包含它们的衍生物和药物成分,并由此治疗癌症
展开▼
页面导航
摘要
著录项
相似文献
摘要
A pharmaceutical composition is provided having particles of a physical mixture that contain at least one 20-camptothecin or a derivative thereof, at least one surfactant, at least one stabilizer, and at least one diluent. The particles have a mean particle size of less than about 2500 nm. The pharmaceutical composition can be nano- or micro-sized particles containing the 20-camptothecin esters or derivatives thereof as part of a physical mixture, which can provide the active compound in a water-soluble/dispersible, bioavailable form. The particles can be used as an oral pharmaceutical composition which comprises the nano- or micro-sized form of 20-camptothecin esters or derivatives, such as in an oral suspension (e.g., an aqueous suspension), or capsules, or caplets. The pharmaceutical composition can be used in the treatment of a cancer or malignant tumor in a patient by oral administration thereof in a therapeutically effective amount.
展开▼