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RADIOPROTECTANTS TARGETING THROMBOSPONDIN-1 AND CD47
RADIOPROTECTANTS TARGETING THROMBOSPONDIN-1 AND CD47
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机译:靶向凝血酶1和CD47的无线电防护
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摘要
Described herein is the discovery that cell and tissue survival can be dramatically increased following radiation exposure through inhibition of the interaction between TSP-1 and CD47. This effect is shown using antisense molecules, peptides, and antibodies, which can now be used as radioprotectant agents. These agents find application in minimizing, reducing and/or preventing tissue damage following intentional and accidental radiation exposure, as well as increasing the therapeutic efficacy of radiation therapies by protecting non-target tissue from incidental radiation damage and by increasing tumor ablation following radiation treatment.
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