METHODS FOR INCREASING SENSITIVITY OF DETECTION AND/OR QUANTIFICATION OF NEGATIVELY CHARGED ANALYTES

摘要

This technology provides a kind of negatively charged analyte, such as the method for increasing sensitivity of detection of an oligonucleotide and/or quantitative, uses the analysis system including liquid chromatography and mass-spectrometry. Method includes the metal ion at least partly removing or shifting the charge sites being adsorbed onto fluid passage from mobile phase liquid reservoir to detector by a fluid passage by analysis system even if an acid solution.