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IDENTIFICATION OF CLASS I MHC ASSOCIATED GLYCOPERTIDES AS TARGETS FOR CANCER IMMUNOTHERAPY
IDENTIFICATION OF CLASS I MHC ASSOCIATED GLYCOPERTIDES AS TARGETS FOR CANCER IMMUNOTHERAPY
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机译:识别I类MHC相关糖苷作为癌症免疫治疗的目标
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摘要
Provided are compositions that include one or more peptides, wherein each peptide is at least 8 amino acids long and has an amino acid sequence as set forth in any of SEQ ID NOs: 1-45. Also provided are in vitro populations of dendritic cells that include the disclosed compositions, in vitro populations of CD8+ T cells capable of being activated upon being brought into contact with the disclosed populations of dendritic cells, antibodies or antibody-like molecules that specifically bind to complexes of MHC class I molecules and the disclosed peptides, methods for treating and/or preventing cancer such as leukemia using the disclosed compositions and/or populations, methods for making cancer vaccines using the disclosed compositions, methods for screening target peptides for inclusion in an immunotherapy composition, methods for determining a prognosis of a leukemia patient, and kits that include at least one of the disclosed peptides.
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机译:提供了包括一个或多个肽的组合物,其中每个肽长至少8个氨基酸,并且具有如SEQ ID NO:1-45中任一个所示的氨基酸序列。还提供了包括所公开的组合物的树突细胞的体外群体,能够与所公开的树突细胞群体接触后能够被活化的CD8 + T细胞的体外群体,特异性结合复合物的抗体或抗体样分子。 I类MHC分子和所公开的肽,使用所公开的组合物和/或群体治疗和/或预防癌症如白血病的方法,使用所公开的组合物制备癌症疫苗的方法,筛选包括在免疫疗法中的靶标肽的方法组合物,用于确定白血病患者预后的方法以及包括至少一种所公开的肽的试剂盒。
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