METHOD FOR ASSESSING OR SELECTING SEBACEOUS-GLAND- OR HAIR-FOLLICLE-SELECTIVE ANDROGEN RECEPTOR ACTIVITY CONTROLLING AGENT

摘要

The present invention provides a method of identifying an agent which can rapidly and accurately regulate activity of androgen receptors in a sebaceous gland- and hair follicle-selective manner. A method of evaluating or selecting an androgen receptor activity regulator selective to sebaceous glands or hair follicles, the method comprising: (A) applying a test agent to cells from sebaceous glands or hair follicles under a hypoxic condition; (B) measuring HIF1± activity in the cells; (C) comparing the HIF1± activity measured in the (B) with HIF1± activity in a control group; and (D) determining a regulatory effect of the test agent on the HIF1± activity based on the result in the (C).