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PHARMACEUTICALLY ACCEPTABLE SALTS OF -GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF
PHARMACEUTICALLY ACCEPTABLE SALTS OF -GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF
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机译:具有改进性质的-胍基丙酸的药学上可接受的盐及其用途
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摘要
The present invention relates to new pharmaceutical salts of β-GPA which exhibit improved physical properties. In particular, the invention relates to salts of β-GPA with improved flow properties (e.g., improved Carr's index and/or Hausner ratio) such as fumarate salts, succinate salts, and oxalate salts. The invention also relates to pharmaceutical compositions including a pharmaceutically effective amount of one or more salts of β-GPA, as well as methods of treating cancer including administration of a formulation including a β-GPA salt of the invention to a subject in need thereof.
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