METHOD FOR CONTROLLING SEXUAL BEHAVIOUR AND CONTRACEPTION IN FEMALE MAMMALS

摘要

The invention relates to the veterinary field in particular to a method for temporarily blocking sexual functions in female mammals, including behavioural phenomena (search for a partner, vocalization, etc.). The method for controlling sexual behaviour and contraception in female animals comprises administration of melatonin, gestagen and ±-adrenergic blocking agent tropic to the posterior nuclei of the hypothalamus, while the combination of specified biologically active substances (BAS) is administered in therapeutic doses once during any period of the estrous cycle. A pharmaceutical composition for controlling sexual behaviour of female animals intended for the "Spot-on" transdermal administration, having pH in the range of 4.0 to 6.0 and containing therapeutic quantities of melatonin, gestagen and ±-adrenergic blocking agent tropic to the posterior nuclei of the hypothalamus with the following ratio of the components (mass%): gestagen - therapeutic quantities; melatonin - therapeutic quantities; ±-adrenergic blocking agent tropic to the posterior nuclei of the hypothalamus - therapeutic quantities; N-methyl-N-(1,2 R ,3 R ,4 R ,5 S -pentahydroxyhexyl)-octadecanamide - 0.5; D -panthenol - 0.5; polyoxyethylated ±-tocopherol - 10; polyoxyethylated lanolin - 1; 3-(octadecyloxy)-1,2-propanediol - 0.1; carboxylic acid - 0.1-1.1; N,N-diethyltoluamid - 15; 1,2-isopropylidene glycerol - 20; 1,2,3-triacetoxypropane - up to 100. The invention makes it possible, while using the minimal dose of the steroid hormone harmful to health of animals, to inhibit sexual behaviour of female animals for the period of 2 months to half a year (depending on the length of the daytime period). The pharmaceutical composition is intended for transdermal administration. The pharmaceutical composition also can be used in humane medicine for effective and safe contraception in the form of metered dose transdermal sprays for convenient application.