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ACTIVATION OF IMMUNE-RELATED SIGNALLING PATHWAYS IN CELLS VIA OPTOFECTION
ACTIVATION OF IMMUNE-RELATED SIGNALLING PATHWAYS IN CELLS VIA OPTOFECTION
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机译:通过光激活细胞中与免疫相关的信号通路
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摘要
Systems and methods of inducing large-scale optical transfection and generation of an immune response in target cells are presented. In preferred aspects large-scale optofection uses nanoparticles with target specific affinity moieties to generate cavitation events proximal to the cell membrane of cells to which the nanoparticles are attached, and suspended and/or dissolved cargo is so provided access into the cell. Notably, cells can be transfected in very large quantities at high viability, with the transfected cells exhibiting up-regulated immune responses.
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