IDENTIFICATION OF INSTANCE-SPECIFIC SOMATIC GENOME ALTERATIONS WITH FUNCTIONAL IMPACT

摘要

The present application provides methods for the identification of somatic genome alterations with functional impact in the genome of a tumor. In several embodiments, the methods comprise generating a bipartite causal Bayesian network with maximal posterior probability including causal edges pointing from genes including somatic mutations and somatic copy number alterations in the genome of the tumor to genes having differential expression in the tumor. The methods can be used, for example, to identify driver somatic genome alterations in the genome of a tumor.