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ANTIBODIES RECOGNIZING THE N-TERMINAL PART OF TISSUE FACTOR PATHWAY INHIBITOR CAPABLE OF ELICITING PRO-COAGULANT ACTIVITY
ANTIBODIES RECOGNIZING THE N-TERMINAL PART OF TISSUE FACTOR PATHWAY INHIBITOR CAPABLE OF ELICITING PRO-COAGULANT ACTIVITY
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机译:识别组织因子通路抑制子能力的N末端抗原,可激发促凝活性
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摘要
The present invention relates to an antibody that specifically binds to an epitope in the N-terminal part (residues 1 to 79) of tissue factor pathway inhibitor (TFPI). An antibody according to the invention may be capable of neutralising TFPI inhibition of the TF/FVIIa complex, even in the presence of elevated levels of TFPI. Such antibodies may find utility in the treatment of subjects with a coagulopathy, such as those with haemophilia A or B, with or without inhibitors.
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