IMMUNOLOGICAL COMPOSITIONS CONTAINING ATTENUATED HISTOPHILUS SOMNI

摘要

This disclosure provides attenuatedstrains, compositions comprising same, and methods of production and use thereof. The attenuated strains may express lower or no levels of various virulence-associated genes, relative to the corresponding pathogenic bacteria Advantageously, the attenuatedstrains may be administered orally, intranasally, intra-tracheally, or subcutaneously.