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METABOLOMIC PROFILING DEFINES ONCOGENES DRIVING PROSTATE TUMORS

机译:代谢组学定义驱动前列腺肿瘤的致癌物

摘要

The invention provides methods and products to identify metabolic status of Aktl and Myc in tumors, and to treat cancer. The method comprises performing an assay to measure a profile of metabolites in a prostate tumor sample obtained from a subject, wherein the metabolites are differentially produced in prostate tumors with high Aktl expression versus prostate tumors with high Myc expression; and comparing, with at least one processor, the profile of metabolites with an appropriate reference profile of the metabolites to assign an Aktl and Myc metabolic status to the sample based on results of the comparison.
机译:本发明提供了鉴定Akt1和Myc在肿瘤中的代谢状态并治疗癌症的方法和产品。该方法包括进行测定以测量从受试者获得的前列腺肿瘤样品中代谢产物的谱的测定,其中所述代谢产物在具有高Akt1表达的前列腺肿瘤与具有高Myc表达的前列腺肿瘤中差异产生。并与至少一个处理者比较代谢物的分布图和代谢物的适当参考分布图,以根据比较结果为样品分配Aktl和Myc代谢状态。

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