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COMPOUND HAVING ANTICANCER ACTIVITY, AND PREPARATION METHOD AND APPLICATION THEREOF

机译：具有抗癌活性的化合物及其制备方法和应用

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摘要

The present invention provides a compound of the formula I, a process for its preparation and the use of a medicament for the treatment of cancer. The compound of the present invention has an inhibitory effect on various cancer cells and can be biologically converted into the active drug Linifanib in vitro (in liver homogenate and spleen homogenate) to inhibit the proliferation of tumor cells, especially liver cancer cells, at a lower dose.

机译：本发明提供了式I的化合物，其制备方法以及药物在治疗癌症中的用途。本发明的化合物对多种癌细胞具有抑制作用，并且可以在体外（肝脏匀浆和脾匀浆）生物转化为活性药物Lififanib 以抑制肿瘤细胞的增殖，特别是较低剂量的肝癌细胞。 展开▼

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公开/公告号EP3543228A1

专利类型

公开/公告日2019-09-25

原文格式PDF

申请/专利权人 3D MEDICINES (BEIJING) CO. LTD.;
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申请/专利号EP20170871197

发明设计人 GONG JOHN;LIN YIHUI;LI FENGQING;TANG FANGQIANG;
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申请日2017-11-17

分类号C07D231/56;A61K31/416;A61P35;

国家 EP

入库时间 2022-08-21 12:28:23

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