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FIVE-MEMBERED HETEROARYL RING BRIDGED RING DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF
FIVE-MEMBERED HETEROARYL RING BRIDGED RING DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF
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机译:五元杂种环桥环衍生物,其制备方法及其医学用途
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摘要
The present invention relates to a five-membered heteroaryl ring bridged ring derivative, a preparation method therefor and the medical use thereof. In particular, the present invention relates to a new five-membered heteroaryl ring bridged ring derivative as shown in formula (I), a preparation method therefor and a pharmaceutical composition comprising the derivative, and the use thereof as a therapeutic agent, in particular as a TGF-β inhibitor, and the use in the preparation of a drug for treating, preventing or reducing cancers mediated by the over-expression of TGF-β, wherein the definition of each substituent in the general formula (I) is the same as defined in the description.展开▼
机译:五元杂芳基环桥连环衍生物,其制备方法及其医学用途。特别地,本发明涉及式(I)所示的新的五元杂芳基环桥连环衍生物,其制备方法和包含该衍生物的药物组合物,及其作为治疗剂的用途,特别是作为TGF-β抑制剂,以及在制备用于治疗,预防或减少由TGF-β过表达介导的癌症的药物中的用途,其中通式(I)中每个取代基的定义与在说明中定义。 <图像文件=“ IMGA0001.GIF” he =“ 35” imgContent =“ chem” imgFormat =“ GIF” wi =“ 53” /> Chemistry>
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