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SOLUBLE HIGH MOLECULAR WEIGHT (HMW) TAU SPECIES AND APPLICATIONS THEREOF
SOLUBLE HIGH MOLECULAR WEIGHT (HMW) TAU SPECIES AND APPLICATIONS THEREOF
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机译:可溶性高分子量TAU物种及其应用
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摘要
The disclosure provides novel forms of tau species and applications thereof, as well as methods of diagnosing and/or treating tau-associated neurodegeneration. the inventors have shown that tau-null neurons lacked activation of AP-induced mitochondrial intrinsic caspase cascades in the neurons and were subsequently protected from A3-induced dendritic spine loss and neurodegeneration. Accordingly, embodiments of various aspects described herein relate to compositions comprising soluble HMW tau species that is responsible for inter-neuron propagation and applications thereof. Methods of treating and diagnosing tau-associated neurodegeneration in a subject are also provided herein.
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