PRODRUGS OF FLUORINATED ACYCLIC NUCLEOSIDE PHOSPHONATES

摘要

The present invention relates to novel phosphonoamidate prodrugs of acyclic nucleoside phosphonates with a 3-fluoro-2-(phosphonomethoxy)propyl side chain. The invention also relates to the use of these novel phosphonate-modified nucleosides to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with viruses such as the hepatitis B virus, the human immunodeficiency virus, the human cytomegalovirus and the varicella zoster virus.