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SURFACE ACOUSTIC WAVE BIOSENSOR EMPLOYING AN ANALOG FRONT END AND DNA ENCODED LIBRARIES TO IMPROVED LIMIT OF DETECTION (LOD) WITH EXEMPLARY APPARATUS OF THE SAME
SURFACE ACOUSTIC WAVE BIOSENSOR EMPLOYING AN ANALOG FRONT END AND DNA ENCODED LIBRARIES TO IMPROVED LIMIT OF DETECTION (LOD) WITH EXEMPLARY APPARATUS OF THE SAME
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机译:使用模拟前端和DNA编码库的表面声波生物传感器,通过相同的示例性仪器提高了检测限(LOD)
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摘要
A surface acoustic wave (SAW) performs a rapid, label-free detection of biological species. Biosensing and detection of multiple analytes multiplexed by an array of sensing lanes is configured to enable bio-amplification using engineered DNA encoded libraries as the probe through a phage display procedure to enhance specificity, capture statistics for the detection, screening and analyzing of the analyte in vitro. A biochemical formulation minimizes the limit of detection (LOD) at a threshold magnitude on the order of a femtomolar concentration. Additional enhancement of the apparatus is achieved by use of an analog front end to amplify biochemical events.
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