URETHRAL DEVICES FOR TREATMENT OF PATHOLOGICAL UROLOGICAL CONDITIONS

摘要

A newly identified problem with conventional treatments of overactive bladder and nocturia is that these diseases are not simply due to dysfunctional bladder detrusor smooth muscle, but rather is a complex disorder involving interplay between sensory and motor nerves. Thus, although the use of anti-muscarinic agents alone can be useful in some women, we discovered that treatment therapy using agents that have mixed-activity anti-cholinergic activity can be especially useful. Further, because absorption of a drug across cell layers is affected by the lipid solubility of the drug, this invention also optionally includes adjusting the pH of the suppository to affect the relative concentrations of charged (polar) and uncharged (non-polar) forms of the drug.