CULTURED TRANSGENIC CELL ALLOWING GROWTH OF NOROVIRUS, AND USE THEREOF

摘要

The present invention addresses the problem of providing a cultured transgenic cell and a transgenic animal, in which mouse norovirus (MNV) can grow beyond the barrier of host characteristics in mammalian cells, and use of the same in a screening method to thereby dissolve stagnation of studies on noroviruses. The present inventor has solved the aforesaid problem by finding that MNV infection is observed in a cultured transgenic mammalian cell, in which the whole or a part of mouse CD300F gene and/or CD300 family gene(s) being similar to mouse CD300F gene in a base sequence in an extracellular domain are incorporated, or a mammal having the aforesaid transgenic cells as own cells and, on the basis of this finding, providing a method for screening a norovirus-related drug etc.