USE OF ANTIBODY AGAINST O-ACETYLATED GD2 GANGLIOSIDE TO IMPROVE THE THERAPEUTIC POTENTIAL OF DRUGS

摘要

The present disclosure relates to a composition for delivery of an anti-cancer agent into a cell, expressing the OAcGD2 ganglioside comprising: (i) at least one anti-cancer agent, and (ii) at least one antibody recognizing the OAcGD2 ganglioside, wherein the at least one antibody recognizing the OAcGD2 ganglioside enhances the uptake of the at least one anti-cancer agent by the tumor cell. The antibody is known and is named the 8B6 antibody. Several variants of the variable claimed, including consensus sequences. Experimental results are provided for a limited number of anti-cancer agents (topotecan, doxorubicin, temozolomide). Combined therapy with said agents show a more potent anti-tumor efficacy.