DIASPIRIN-CROSSLINKED PEG HEMOGLOBIN

摘要

To provide PEGylated hemoglobin having high oxygen affinity and hemoglobin compositions for reducing nitrite to nitrogen oxide at an enhanced rate in microvessel systems as compared with naturally occurring hemoglobin.SOLUTION: Disclosed herein is a β,β-intramolecularly crosslinked polyethylene oxide hemoglobin tetramer conjugate having a P50 ranging from 2 to 5 mmHg as measured at 37°C and pH7.4, which exhibits, when fully deoxygenated at 25°C, maximum nitrite reductase activity at least 10 times as large as that of deoxygenated stroma-free hemoglobin when measured at the same conditions.SELECTED DRAWING: Figure 5