NOVEL CATIONIC POLYPHOSPHAZENE COMPOUNDS, POLYPHOSPHAZENE-DRUG CONJUGATE COMPOUNDS AND METHODS FOR PREPARING THE SAME

摘要

To provide new substances which have excellent cancer tissue selectivity and very low toxicity and are likely to be implemented as anticancer drugs.SOLUTION: The present invention can apply: cationic linear polyphosphazene compounds into which a hydrophilic poly(ethylene glycol) and a spacer group selected from the group consisting of lysine, oligopeptides containing lysine, amino-ethanol, amino-propanol, amino-butanol, amino-pentanol and amino-hexanol are introduced; polyphosphazene-drug conjugate compounds obtained by chemically bonding hydrophobic drugs to the compounds; and preparation methods thereof.SELECTED DRAWING: Figure 12