METHODS FOR REDUCING RISKS ASSOCIATED WITH HEART FAILURE AND FACTORS ASSOCIATED THEREWITH

摘要

To provide compositions for preventing or treating heart failure in mammalian subjects, for reducing risk factors related to heart failure and/or reducing likelihood or severity of heart failure.SOLUTION: Disclosed herein is a composition comprising a therapeutically effective amount of a peptide D-Arg-2',6'-Dmt-Lys-Phe-NHor pharmaceutically acceptable salt thereof for reducing level(s) of one or more of C-reactive protein, reactive oxygen species, interleukin 6, TNFα, cardiac troponin I, NT-pro BNP, expression levels of MLCL AT1 and ALCAT1 and/or increasing Taz1 expression in a mammalian subject in need thereof.SELECTED DRAWING: Figure 1