Crystalline polymorphs of kinase inhibitor compounds, pharmaceutical compositions containing the same, methods for their production and applications

摘要

The present invention discloses crystalline polymorphs of the compounds of formula I, pharmaceutical compositions containing them, and their preparation and application. The compound of formula I of the present invention is as shown in formula I, and its crystal form is crystal form 1, crystal form 2, crystal form 3, crystal form 5, crystal form 6 or crystal form 7. The crystal form stability and chemical stability of each crystal form of the compound of formula I of the present invention is good, and the purity reduction of the chemical stability main component is less than 2%. Each of the crystalline forms of the compound of formula I with high purity can be produced by the production method of the present invention, and the formulation method is suitable for large-scale production. [Chemical 1]