GENERATION OF HIGHLY POTENT ANTIBODIES NEUTRALIZING LUKGH (LUKAB) TOXIN OF STAPHYLOCOCCUS AUREUS

摘要

To provide an antibody directed against the Staphylococcus aureus cytotoxin LukGH (also called LukAB) that is cross-reactive among the different variants of this toxin.SOLUTION: The subject relates to an isolated Staphylococcus aureus leukocidin antigen comprising a LukGH complex, an antibody specifically binding to the Luk GH complex, and the human CD11b/CD18 complex for use in a method of determining the binding or toxicity of the Staphylococcus aureus Luk GH bi-component cytolysin.SELECTED DRAWING: None