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QUALITY IMPROVING METHOD OF TABLET CONTAINING AZILSARTAN OR SALT THEREOF AND AMLODIPINE OR SALT THEREOF, AS WELL AS TABLET CONTAINING AZILSARTAN OR SALT THEREOF AND AMLODIPINE OR SALT THEREOF, AND PRODUCTION METHOD THEREOF
QUALITY IMPROVING METHOD OF TABLET CONTAINING AZILSARTAN OR SALT THEREOF AND AMLODIPINE OR SALT THEREOF, AS WELL AS TABLET CONTAINING AZILSARTAN OR SALT THEREOF AND AMLODIPINE OR SALT THEREOF, AND PRODUCTION METHOD THEREOF
PROBLEM TO BE SOLVED: To provide methods for improving quality of a tablet containing azilsartan or a salt thereof and amlodipine or a salt thereof which can have both improved drug stability and suppression of lowered tablet hardness, as well as to provide tablets containing azilsartan or a salt thereof and amlodipine or a salt thereof which have improved drug stability and suppression of lowered tablet hardness, and production methods thereof.;SOLUTION: The present invention provides a method for improving quality of a tablet containing azilsartan or a salt thereof and amlodipine or a salt thereof, the method comprising: granulating a composition containing azilsartan or a salt thereof to prepare a granule containing azilsartan or a salt thereof; granulating a composition containing amlodipine or a salt thereof to prepare a granule containing amlodipine or a salt thereof; compression molding a mixture containing the granule containing azilsartan or a salt thereof, the granule containing amlodipine or a salt thereof, and low substituted hydroxypropylcellulose, the improved quality comprising improved drug stability and suppress of lowered tablet hardness.;SELECTED DRAWING: None;COPYRIGHT: (C)2019,JPO&INPIT
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