CRYSTALLINE SOLVATES AND COMPLEXES OF (1S)-1,5-ANHYDRO-1-C-(3-((PHENYL)METHYL)PHENYL)-D-GLUCITOL DERIVATIVES HAVING AMINO ACIDS AS SGLT2 INHIBITORS FOR TREATING DIABETES

摘要

To provide novel free acid polymorphic crystals of SGLT2 inhibitors, production methods of the crystals, and pharmaceutical compositions containing the crystals, which possess an effect of inhibiting the sodium dependent glucose transporters (SGLT2) in the intestine and kidney of mammals and are useful in treatment of diabetes, diabetic complications, and the like.SOLUTION: The invention provides a crystal of a compound I represented by the formula in the figure, which is selected from the group consisting of ethylene glycol (EG) crystal (form SB-1), ethylene glycol (EG) crystal (form SB-2), 1:2 L-proline crystal (form 3), 1:1 L-proline crystal (form 6), and 1:1 L-proline hemihydrate crystal (form H.5-2).SELECTED DRAWING: None