To provide a Tie2 activator, angiogenesis inhibitor, vascular maturing agent, vascular normalizing agent and vascular stabilizing agent, a pharmaceutical composition, and food and drink, having excellent Tie2 activation action, angiogenesis inhibiting action, vascular maturing action, vascular normalizing action, and vascular stabilizing action, and high safety.SOLUTION: The present invention provides a Tie2 activator, vascular maturing agent, vascular stabilizing agent, and oral composition containing, as an active ingredient, at least one of extract from an embryonic part of lotus with water, hydrophilic solvent, or mixed solvent of water and hydrophilic solvent, and extract from a fruit part of Chaenomeles sinensis with water, hydrophilic solvent, or mixed solvent of water and hydrophilic solvent.SELECTED DRAWING: None
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