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Glycoengineering of E-selectin ligand

机译:E-选择蛋白配体的糖工程

摘要

The present invention provides methods of forcing expression of E-selectin and / or L-selectin ligands on the surface of cells. Also, a method of enabling and / or increasing binding of cells to E-selectin and / or L-selectin, a method of increasing homing and / or extravasation in a population of transplanted cells, for transplantation into a subject Methods of making cells comprising modified stem cells, methods of treating or ameliorating the effects of a condition, disease or injury in a subject, and inducing and / or enhancing homing of a population of cells to a therapeutic target in a subject Methods are also provided. The invention further provides a pharmaceutical composition comprising a population of cells produced by the method of the invention, as well as a kit comprising such a composition for treating or ameliorating the effects of a condition, disease or injury in a subject. Do.
机译:本发明提供了迫使E-选择蛋白和/或L-选择蛋白配体在细胞表面上表达的方法。另外,一种使细胞能够和/或增加与E-选择蛋白和/或L-选择蛋白的结合的方法,一种增加被移植细胞群体中归巢和/或外渗的方法,用于移植到受试者体内。还提供了修饰的干细胞,在受试者中治疗或改善病症,疾病或损伤的影响以及在受试者中诱导和/或增强细胞群体向治疗靶标归巢的方法。本发明进一步提供了包含通过本发明的方法产生的细胞群的药物组合物,以及包含该组合物的试剂盒,所述试剂盒用于治疗或改善受试者的病症,疾病或损伤的作用。做。

著录项

  • 公开/公告号JP2019516382A

    专利类型

  • 公开/公告日2019-06-20

    原文格式PDF

  • 申请/专利权人 サックステイン;ロバート;

    申请/专利号JP2018560978

  • 发明设计人 サックステイン;ロバート;

    申请日2017-05-22

  • 分类号C12N15/54;C12N9/12;C12P21/02;A61K35/545;A61K35/28;A61P29;A61P35;A61P37/06;A61P9;A61P3;A61L27/36;A61L27/38;

  • 国家 JP

  • 入库时间 2022-08-21 12:23:01

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