Amine solvate of sodium-glucose coupled transporter inhibitor, preparation method thereof and application thereof

摘要

Disclosed are amine solvates of sodium-glucose coupled transporter (SGLT) inhibitors, methods for their preparation and their applications. The SGLT inhibitor is (1S, 2S, 3S, 4R, 5S) -5- (3-((2,3-dihydrobenzo [b] [1,4] dioxin-6-yl) methyl) -4-ethyl Benzyl) -1- (hydroxymethyl) -6,8-dioxabicyclo [3.2.1] octane-2,3,4-triol. Also provided is a crystalline compound of an amine solvate, a pharmaceutical composition comprising the amine solvate, and the application of the amine solvate in the preparation of a SGLT inhibiting pharmaceutical.