Eradication of human JC virus and other polyoma viruses induced by RNA

摘要

The invention includes methods and compositions for removing polyoma virus such as John Cunningham virus (JVC) from host cells and treating polyoma virus related diseases such as progressive multifocal leukoencephalopathy (PML) . The composition comprises an isolated nucleic acid sequence comprising a CRISPR-related endonuclease and a guide RNA, wherein the guide RNA is complementary to a target sequence in a polyoma virus. [Selected figure] Figure 1A