Prodrugs of cytotoxic active agents having an enzyme cleavable group

摘要

The present invention is a novel prodrug of general formula (Ia), which releases an active agent, for example, that a cytotoxic active agent such as a kinesin spindle protein inhibitor is masked by a group cleavable by legumain Or a complex. The invention further relates to the use of said prodrugs or complexes for the treatment and / or prophylaxis of a disease, and the treatment and / or treatment of a disease, for example in certain hyperproliferative and / or angiogenic diseases such as cancer. It relates to the use of said prodrug or conjugate for the manufacture of a medicament for the prevention. [Chemical formula 1]