Methods of using (2R, 6R) -hydroxynorketamine and (2S, 6S) -hydroxynorketamine in the treatment of depression, anxiety, anhedonia, fatigue, suicidal ideation, and post-traumatic stress disorder

摘要

Psychotic depression, suicidal ideation, severe mood control disorder, persistent depressive disorder (moodness modulation), premenstrual dysphoric disorder, substance / drug-induced depressive disorder, depressive disorder due to other medical conditions, other specific depressive disorder, Unspecified depressive disorder, separation anxiety disorder, selective abortion, specific phobia, social anxiety disorder (social phobia), panic disorder, panic attack (specific term), agoraphobia, generalized anxiety disorder, substance / drug A method of treating induced anxiety disorder, anxiety disorder due to other medical conditions, other specific anxiety disorder, unidentified anxiety disorder, or fatigue, comprising: purified (2R, 6R) -hydroxynorketamine, purified (2S, 6S) A pharmaceutical composition comprising an effective amount of an active agent which is a hydroxynorketamine, or a combination thereof, or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier. A method which comprises administering to a patient in need of such treatment is disclosed.