Selectively Deregulated Markers in Tumor Invasive Regulatory T Cells

摘要

The present invention discloses a number of markers that are selectively deregulated in tumor invasion regulatory T cells. The present invention relates to molecules capable of modulating the expression and / or function of at least one such marker, for use in tumor arrest and / or treatment. Preferably, the molecule specifically binds to the marker and elicits antibody dependent cell mediated cytotoxic activity (ADCC). The invention further provides a molecule capable of modulating the expression and / or function of at least one such marker, for use in a method for depleting tumor invasion regulatory T cells in a subject in vivo Said molecules for use in, or for use in a method for enhancing tumor immunity in a subject. Corresponding pharmaceutical compositions are also contemplated. 【Selection chart】 None