Pharmaceutical composition comprising a delivery system, an amide type local anesthetic, and meloxicam

摘要

A composition comprised of a delivery vehicle or delivery system and an active agent dispersed in the delivery vehicle or delivery system, the delivery vehicle or delivery system comprising a polyorthoester polymer and a polar aprotic solvent. Composition. Also disclosed is a low viscosity delivery system for the administration of active agents. The low viscosity delivery system has a solvent containing a polyorthoester polymer, a polar aprotic solvent, and a triglyceride viscosity reducing agent. The compositions described include amide or anilide type local anesthetics of the “caine” class, and non-steroidal anti-inflammatory drugs (NSAIDs), eg for treating post-operative pain or for prophylactic treatment of pain With related methods for. This composition is suitable, for example, for direct application and instillation, intradermal injection, subcutaneous injection, and delivery by nerve blocks (perineural).