Interleukin-10 and its use in the production of antigen-specific CD8 + T cells

摘要

The present disclosure relates to an isolated CD8 + T cell that expresses a disease antigen-specific T cell receptor, and a nucleic acid encoding a Vα and Vβ polypeptide pair of the T cell receptor (TCR) of such disease antigen-specific T cell. Related methods and compositions are provided. Such disease antigen-specific CD8 + T cells can be obtained from the periphery (eg, blood) of a subject having a disease that is amenable to treatment with an IL-10 agent. The disclosure also provides therapeutic methods and compositions relating to administration of isolated disease antigen-specific CD8 + T cells to a subject, as well as CD8 + T genetically modified to express a disease antigen-specific TCR and / or chimeric antigen receptor. Therapeutic methods and compositions relating to cells are contemplated. [Selection] Figure 5