Array-based peptide library for characterization of therapeutic antibodies

摘要

The present specification provides methods, compound libraries and simulation systems for performing in situ patterned chemistry. Also, methods, systems and assays involving the use of synthesized compound libraries, which increase the protein space explored in a knowledge-based manner, characterize antibody-target interactions (identify target proteins of antibodies Providing, characterizing the antibody binding region in the target protein, identifying linear and structural epitopes in the target protein, and determining the nature of the antibody binding to the target protein.