Nanoparticles for gene delivery for oral administration and pharmaceutical composition comprising the same

摘要

The nanoparticle for gene transfer according to the present invention is a novel oral gene delivery system capable of sensing an ingested meal and regulating blood glucose level and insulin secretion in a biological system, and a nanoparticle for gene delivery for oral administration. More specifically, the present invention relates to gene transfer nanoparticles containing ionic polymers and genes to which bile acids or bile acid derivatives are covalently linked, and pharmaceutical compositions containing the same. [Selected figure] Figure 1