Methods and compositions for the prevention and treatment of post-surgical adhesions

摘要

Aspects of the present disclosure include methods of treating a subject to reduce adhesion formation, the methods comprising administering to a subject in need thereof an agent that targets adhesion formation by damaged mesothelial cells. Drugs are targeted to target damaged mesothelial cells to be destroyed, mobilize inflammatory macrophages to adhesion sites, block neutrophil recruitment to adhesion sites, and / or induce expression in damaged mesothelial cells. Can act at various checkpoints involved in the development of adhesions by damaged mesothelial cells, including inhibition of the expression or activity of the gene product. Also provided are compositions and kits for practicing this method.