A scalable, high recovery method for producing high yields of recombinant adeno-associated virus (rAAV) vectors and the recombinant adeno-associated virus (rAAV) vectors produced thereby

摘要

Methods are provided for producing recombinant adeno-associated virus (rAAV) vector particles with high recovery or high titer. Also provided are methods for concentrating rAAV vectors at high concentrations to, for example, 5E + 13 (5 × 1013) vector genomes per milliliter (Vg / ml) without or nearly without rAAV aggregates. [Selection] Figure 1