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Blood tests to screen out the presence of amyloid and Alzheimer's disease

机译:血液检查以筛查淀粉样蛋白和阿尔茨海默氏病的存在

摘要

The invention comprises obtaining a blood or serum sample from a patient in a primary care setting; the following proteins: FABP, beta2 microglobulin, PPY, soluble tumor necrosis factor receptor 1 (sTNFR1), CRP, VCAM-1, thrombopoietin, α2 macroglobulin, eotaxin 3, tumor necrosis factor-alpha (TNF-α), tenascin C (TNC), IL-5, IL-6, IL-7, IL-10, IL-18, I309, factor VII, Determining the expression level of at least four of the thymus and activation controlling chemokine (TARC), serum amyloid A (SAA), and intercellular cell adhesion molecule-1 (ICAM-1); Compared to statistical samples of a multi-ethnic, broad age range And the patient from the need for further analysis of Alzheimer's disease, including determining whether the patient will be excluded from further testing for Alzheimer's disease, thereby eliminating the need for further testing of the patient Including methods for excluding.
机译:本发明包括在初级保健机构中从患者那里获得血液或血清样品。下列蛋白质:FABP,β2微球蛋白,PPY,可溶性肿瘤坏死因子受体1(sTNFR1),CRP,VCAM-1,血小板生成素,α2巨球蛋白,嗜酸性粒细胞趋化因子3,肿瘤坏死因子-α(TNF-α),腱糖蛋白C(TNC) ),IL-5,IL-6,IL-7,IL-10,IL-18,I309,因子VII,确定至少四个胸腺和激活控制趋化因子(TARC)的表达水平,血清淀粉样蛋白A( SAA)和细胞间细胞粘附分子1(ICAM-1);与多族裔,较宽年龄范围的统计样本相比,该患者无需进一步分析阿尔茨海默氏病,包括确定是否将患者排除在进一步测试阿尔茨海默氏病的范围之外,从而消除了对该患者进行进一步检验的需要患者包括方法除外。

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