A new type of taxane compound, its production method and application

摘要

The present invention discloses a new type of taxane compound and its preparation and application. A method for producing a new type of taxane compound comprises the following steps: protecting two hydroxyl groups in gemcitabine, carrying out a condensation reaction between protected gemcitabine and alkyl chloroformate, removing the hydroxyl protecting group and intermediates Obtaining G1, protecting the primary hydroxyl group of intermediate G1, then protecting the other one of the hydroxyl groups and removing the protecting group of the primary hydroxyl group to obtain intermediate G2, 7, Reacting 10-di-troc-docetaxel with dianhydride to obtain intermediate D1, performing a condensation reaction between intermediate D1 and intermediate G2 to obtain intermediate D2, and intermediate A step of subjecting D2 to hydroxyl deprotection to obtain a target compound. The new types of taxane compounds of the present invention have low toxicity and high anti-tumor activity and have good inhibition rates, especially against solid tumors such as leukemia and gastrointestinal cancer, lung cancer and breast cancer.