MULTIVALENT CD20-BINDING MOLECULES COMPRISING SHIGA TOXIN SUBUNIT A EFFECTOR REGION AND ENRICHED COMPOSITIONS THEREOF

摘要

To provide multivalent CD20-binding molecules and compositions thereof, such as enriched compositions comprising a large proportion of the multivalent CD20-binding molecule relative to monovalent CD20-binding molecules.SOLUTION: Certain multivalent CD20-binding molecules of the invention comprise: 1) two or more CD20-binding regions; and 2) one or more Shiga toxin effector polypeptide regions derived from an A Subunit of a member of the Shiga toxin family. Certain multivalent CD20-binding molecules of the invention and compositions thereof have uses for selectively killing certain cell types and as therapeutics for the treatment of a variety of diseases including cancers, tumors, and immune disorders. Certain multivalent CD20-binding molecules of the invention and compositions thereof have uses in delivering agents into CD20-expressing cells, intracellular labeling of CD20-expressing cells, collecting diagnostic information, and monitoring the treatment of variety diseases such as cancers, tumors, and immune disorders which involve CD20-expressing cells.SELECTED DRAWING: None