Composition for maintaining chromosomal stability of pluripotent stem cells containing a small molecule compound

摘要

The present invention relates to a composition for maintaining the chromosome stability of pluripotent stem cells, containing a small-molecule compound and, more specifically, to a composition for maintaining the chromosome stability of induced pluripotent stem cells, containing a ROCK inhibitor, a MEK inhibitor, an ALK5 inhibitor, or an antioxidant for inhibiting structural and numerical mutations or DNA damage of the chromosomes during a step of inducing pluripotent stem cells, an inducing process, and then culturing of the induced pluripotent stem cells. The composition for maintaining the chromosome stability of induced pluripotent stem cells, containing a small-molecule compound, according to the present invention, increases the dedifferentiation rate and efficiency when the induced pluripotent stem cells are produced and has excellent effects for inhibiting structural and numeral mutations of chromosomes, and is thus very useful for developing an induced pluripotent stem cell therapeutic agent having excelling chromosome stability.