CELL-REACTIVE-, LONG-ACTING- OR TARGETED COMPSTATIN ANALOGS, RELATED COMPOSITIONS AND METHODS

摘要

To provide methods for inhibiting complement mediated damage to cells, tissues or organs, e.g., methods for treating complement-mediated disorders.SOLUTION: The invention provides cell-reactive compstatin analogs and compositions comprising the same, as well as long-acting compstatin analogs and compositions comprising the same. In one aspect, a long acting compstatin analog comprises a clearance-reducing moiety attached to two compstatin analog moieties, where the clearance reducing moiety comprises a linear polymer being polyethylene glycol (PEG) or polyoxazoline (POZ), and each end of the linear polymer is linked to one of the compstatin analog moieties.SELECTED DRAWING: None