SPLICE SWITCHING OLIGOMERS FOR TNF SUPERFAMILY RECEPTORS AND USE OF OLIGOMERS IN TREATMENT OF DISEASE

摘要

To provide splice switching oligomers (SSOs) for TNF superfamily receptors, and compositions comprising the SSOs.SOLUTION: An oligomer consisting only of the nucleotide sequence of SEQ ID No. 90, 100, 101, 102 or 103 comprises one or more nucleotides or nucleosides independently selected from the group consisting of 2'O-Me ribonucleotides and 2'O-4'C-linked bicyclic ribofuranosyl (LNA) nucleotides or nucleosides.SELECTED DRAWING: Figure 14