Compositions and methods of vaccines against dengue virus in children and young adults

摘要

Embodiments herein relate to compositions, methods, and uses for inducing an immune response to all four dengue virus serotypes in children or young adults from about 1 to about 20 years of age. Some embodiments include, but are not limited to, Dengue virus chimeras that can be used in vaccine compositions against all four dengue virus serotypes, either alone or in combination with other constructs. It relates to the composition which may be present. In one embodiment, the composition comprises Dengue-1 (DEN-1) virus, Dengue-2 (DEN-2) virus, Dengue-3 (DEN-) to improve protection of children and young adults from infection. 3) Constructs of more than one serotype of Dengue virus, such as virus, and / or Dengue-4 (DEN-4) virus, may be included at various concentrations or ratios. In certain embodiments, the virus of the formulation is limited to dengue virus serotypes. Other embodiments relate to methods of administering an immunogenic composition against dengue virus, which may comprise a chimeric dengue construct and a live attenuated dengue virus, using a single, dual or other regimen.